THE TREATMENT OF EXPERIMENTAL TUMORS WITH BACTERIAL TOXINS.
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چکیده
منابع مشابه
Mixed bacterial toxins in the treatment of tumors. IV. Response of methylcholanthrene-induced, spontaneous, and transplanted tumors in mice.
Different preparations obtained from cultures of Serratia marcescens and Strepto coccus pyogenes were tested in seven spontaneous, induced, and transplanted tumors of mice, and Rous sarcoma in chicks. The toxins were found to be effective against Krebs-2 carcinoma causing regression of well established tumors. They were found to be ineffective against Sarcoma 180, Gardner's Lymphosarcoma 6C3HED...
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Many bacterial toxins are proteins, encoded by the bacterial chromosomal genes, plasmids or phages. Lysogenic phages form part of the chromosome. The toxins are usually liberated from the organism by lysis, but some are shed with outer membrane proteins in outer membrane vesicles. An important non-protein toxin is lipopolysaccharide or endotoxin, which is a constituent of the cell wall of gram ...
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Pyogenic organisms, under conditions simulating a focal infection, are capable of producing in rabbits a granulopenia which may allow generalized infection and death. It is suggested that agranulocytosis in man is due to the action of leucocidin, rather than to a specific microorganism.
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چکیده ندارد.
15 صفحه اولBacterial toxins deliver the goods.
Some toxins produced by bacteria are so potent that scientists have long considered putting them to good use. This became possible when their structures were determined through the combined use of molecular biology and structural biochemistry. The current status of targeted toxin technology is perhaps best illustrated by exotoxin A produced by Pseudomonas aeruginosa, a Gram-negative bacterium t...
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ژورنال
عنوان ژورنال: JAMA: The Journal of the American Medical Association
سال: 1907
ISSN: 0098-7484
DOI: 10.1001/jama.1907.25320180011001c